Alteraciones endocrinológicas en el síndrome de Down / Endocrine disorders in Down’s syndrome

La prevalencia de alteraciones endocrinológicas, generalmente de origen autoinmune, es muy elevada en las personas con síndrome de Down. Por ello, durante toda la vida se debe vigilar la función tiroidea. Es especialmente frecuente el hipotiroidismo, especialmente en su forma subclínica. La delgada línea que separa el hipotiroidismo subclínico del verdadero hace difícil la indicación terapéutica. También la diabetes es más frecuente que en la población general, ocasionalmente asociada a hipotiroidismo (AU)

The prevalence of endocrine disorders, generally of autoimmune origin, is very high in persons with Down’s syndrome. Therefore, the thyroid function should be monitored during the entire lifetime. Hypothyroidism, particularly the subclinical form, is especially common. The thin line separating subclinical hypothyroidism from true hypothyroidism makes the therapeutic indication difficult. Diabetes is also more frequent than in the general population, occasionally associated to hypothyroidism (AU)

[Immunity in hypothyroid children (author's transl)]. / Estudio de la inmunidad en niños hipotiroideos.

For a long time investigators have focused attention on the relationship between specific immunity and hormones. In the present paper, authors investigated on 26 children, 9 males and 17 females, from 9 months to 14 and 10/12 years old, with primary hypothyroidism. All patients were in substitutive treatment. The following studies were done to all the patients: serum IgG, IgA, IgM and complement. Blood lymphocyte counts, percentages of B and T lymphocytes, as well as the response of lymphocytes to PHA. Skin tests were also carried out: tuberculin, candidin and streptokinase-streptodornase. All results obtained in both, hypothyroid and control groups fell within the range of normal age-matched values for our laboratory, and by results of statistics studies carried out they were considered of little significance, except the percentage of circulating B lymphocytes that was lower in hypothyroid group (p less than or equal to 0.01).

[Schwartz-Jampel syndrome. Report of two cases and review of the literature (author's transl)]. / Síndrome de Schwartz-Jampel. Revisión bibliográfica y aportación de dos nuevos casos.

Two cases of Schwartz-Jampel syndrome are reported in addition to the 30 described previously. Authors present a study on the incidence of different signs and symptoms in all cases reviewed by them and on the radiological, biochemical, electromyographic, immunological and pathologic findings of all these cases concluding that the definitive data, present in all of them, is the association of facial dysmorphia, osteomuscular dystrophy and a muscular syndrome of myotonic aspect.

[Obese children. Psychical aspects studied by Rorschach's test (author's transl)]. / Obesidad infantil. Aspectos psíquicos. Estudio mediante el "test" de Rorschach.

A group of obese children comparatively to a control group of normal children using Rorschach's protocols is studied. Quantitatively it doesn't appear significant differences, although a serie of characteristics in obese children (a proportional increase in answer of small detail and human movement, less number of answer of colour-form and animal contents), is found. Cualitatively some differences (desvitalitation phenomenous and shock in front of grey colours) are also found. The present work deduces that it doesn't exist reasons to think about an specific structure and dynamic in personality of obese children.

[Fasting insulinemie levels and after overload with oral glucose in overweight children (author's transl)]. / Estudio de la insulina basal y tras sobrecarga de glucosa en el niño obeso.

Fasting insulinemie levels and after overload with oral glucose are studied in a group of 30 overweight children aged between 2--12 years. The results are: An increase in insulin secretion according to the age only in the overload test. The insulin and glucose areas in the overweight child is statistically bigger than in the healthy child. We conclude that hyperinsulinism in obesity, may be related with a insuline-resistance and with some kind of glucose intolerance.